Controlled deagglomeration, dispersion and true grinding of solid particles in a liquid medium are the principal objectives of wet-milling technology.
WAB has significantly improved the performance of wet-milling technology with the development of new machines and techniques. Particle sizes below 100 nanometres can be achieved, and new industries have learned to appreciate the performance of the DYNO®-MILL grinders.
One of them is the pharmaceutical industry, more precisely to achieve enhanced bioavailability and for sterile productions:
Enhanced bioavailability
Many modern active pharmaceutical ingredients have poor solubility properties. Bioavailability can therefore become a challenge in product development. This is where the DYNO®-Mill pharma wet-milling technology helps: By reducing the particle sizes during wet grinding, the available active ingredient surfaces increase over-proportionately strongly and improve the bioavailability of the active ingredient. Pharmaceutical compounds with a crystalline structure are particularly suitable for mechanical wet milling.
Sterile production
Selected active ingredients are produced under sterile conditions using wet-milling technology. The introduction of a sterile production line is always a challenge and requires close cooperation between the customer and the machine manufacturer. At the start of a project we take the necessary time to clarify all technical requirements and to create a complete requirements specification.
The DYNO®-Mill pharma series offers machines which were specially developed for sterile production. The most important features are:
•Cleaning-In-Place (CIP)
•Sterilization-In-Place (SIP)
•Semi-automatic or fully automatic control of the CIP/SIP process
•Wab scada control system (compliant with 21 CFR Part 11)
•vGMP Machine production
•Material certificates in compliance with FDA requirements
The WAB-Group utilizes its decades of experience in wet-milling technology in the pharmaceutical industry to develop optimum solutions in close partnership with the customers.
